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Patients should be started at high doses(60–80 mg) in severe cases, but lower doses, graduallyincreasing over time, can be employed in particularclinical circumstances. expandingthe number of animals routinely tested is not economicallyfeasible, and even very large studies may not eliminate thisproblem.

Brekman A, Singh KE, Polotskaia A, Kundu N, Bargonetti J (2011) A p53-independent role ofMdm2 in estrogen-mediated activation of breast cancer cell proliferation.

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Committee on Improving RiskAnalysis Approaches Used by the U.S.

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